Postoperative pain is often associated with increased morbidity and dysfunction and can delay time to ambulation and prolong the hospital length of stay¹.

Acute postsurgical pain if not appropriately managed, it may develop into chronic postoperative pain, which may lead to dysfunction, disability, depression, and can be difficult to manage¹.

SYSTEMIC ENZYME THERAPY for PAIN and INFLAMMATION

TRYPSIN

BROMELAIN

RUTOSIDE

INDICATION

Post operative minor surgery

Post operative dental process

Nasal Oedema

BENEFITS

Significantly better than Serratiopeptidase, IN PAIN and INFLAMMATION CONTROL ²

Significantly better than Trypsin-Chymotrypsin, IN REDUCTION OF SWELLING ³

Comparatively higher reduction than NSAIDs IN SWELLING WITH BETTER TOLERABILITY ^4,5

Shown to increases ABSORPTION OF ANTIBIOTICS ³

Facilitate WOUND HEALING ⁴

MODE OF ACTION

Ingredients	Class	Mechanism of Action³
TRYPSIN	Proteolytic Enzyme	Promotes fibrinolysis and breakdown of thrombi Reduces the release of inflammatory mediators
BROMELIN	Proteolytic Enzyme	Reduces vascular permeability and inflammatory cytokine production Inhibits platelet aggregation Prevents thrombi formation
RUTOSIDE	Antioxidant	Reduces tissue damage with its Antioxidant property Reduces vascular permeability

Ingredients

Class

Mechanism of Action³

TRYPSIN

Proteolytic Enzyme

Promotes fibrinolysis and breakdown of thrombi

Reduces the release of inflammatory mediators

BROMELIN

Proteolytic Enzyme

Reduces vascular permeability and inflammatory cytokine production

Inhibits platelet aggregation

Prevents thrombi formation

RUTOSIDE

Antioxidant

Reduces tissue damage with its Antioxidant property

Reduces vascular permeability

EFFICACY

Promising alternative to conventional therapies for pain and edema

Systemic Enzyme Therapy - PHLOGAM

Efficacy of Systemic Enzyme Therapy in Combating Post-Operative Wound Inflammation & Pain

It has been well established that Systemic enzyme therapy (SET) aids better and faster healing when compared to usual antiinflammatory drugs like...

Video Resources

Reference

1)Mayoral Rojals V et al. New Insights Into the Pharmacological Management of Postoperative Pain: A Narrative Review. Cureus. 2022;14(3):e23037. Published 2022 Mar 10. doi:10.7759/cureus.23037
2) Bakhshi et al. Systemic enzyme therapy with trypsin-bromelain-rutoside combination to counter post-operative wound inflammation – a randomised active-controlled multicentre trial. ejpmr, 2019, 6(8), 493–500
3) Tiwari S et al. Int J Sci Rep 2022;8(10)
4) Rajesh dhadiwal et al. Int J of scientific research management of post-surgical inflammation with proteolytic enzyme-bioflavonoid combination volume-10. issue-9. Sep 2021
5) Nanda MS, Kaur M. Role of Oral Enzymes in Post Operative Septoplasty Cases. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 3):1663-1667. doi:10.1007/s12070-014-0814-3

Postoperative pain is often associated with increased morbidity and dysfunction and can delay time to ambulation and prolong the hospital length of stay1.

Acute postsurgical pain if not appropriately managed, it may develop into chronic postoperative pain, which may lead to dysfunction, disability, depression, and can be difficult to manage1.