India's Number #1 Calcium Channel Blocker Brand
About CILACAR 5/10/20 mg tablets
CILACAR (Cilnidipine) is a 4th Generation Dihydropyridine (DHP) calcium channel blocker.It is used for the treatment of Hypertension.
Cilacar is marketed by J.B. Chemicals & Pharmaceuticals Ltd. and comes in three doses namely CILACAR 5 mg, CILACAR 10 mg, CILACAR 20mg.
Cilnidipine is a 4th Generation Dihydropyridine (DHP) calcium antagonist with a slow onset and long duration of action.Calcium antagonist inhibit influx of extracellular calcium ions into the cells, resulting in decreased vascular smooth muscle tone and vasodilation, leading to a reduction in blood pressure.
In human studies, Cilnidipine had weak inotropic effects and suppressed cardiac sympathetic overactivity. Therefore, it may decrease the risk and mortality from long term cardiovascular complications.Once-daily Cilnidipine was associated with less reflex tachycardia and had Fewer effects on the autonomic nervous system in hypertensive patients (see Product Leaflet).
Reduces Arterial Stiffness and Lowers Central Aortic BP1
As efficacious as Amlodipine with better tolerability in hypertensive patients3
Significantly reduces albuminuria in diabetic
Offers Smooth Reduction of Blood Pressure with Less Chances of Hypotension5,6
As efficacious as Amlodipine with better tolerability in Patients with hypertension7
Reduction inHR by 3 beats/min8
Minimal incidence of pedal oedema9
Reduction in uric acid8
Safe and effective in reducing low-grade albuminuria in hypertension CKD patients10
Equal efficacy compared to Amlodipine in BP reduction11
Effective Management of Hypertension with Elevated HR
Sustained BP Control and Superior Neuro Protection
As efficacious as Amlodipine17
BP variability is least with Cilnidipine compared to other CCBs18
Regresses c-IMT & reduces IAD in post - stroke hypertensive patients19
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Download the Product Leaflet, to see the details on Overview of Cilacar.
Indications of Cilacar
Cilnidipine Dose and Method of Administration
The recommended adult oral dosage of Cilnidipine is 5-10 mg once daily. The dosage can be increased up to 20 mg, if needed. Starting dose 5 to 10 mg per day depending on individual case. Maintaining dose- physician will titrate the dose as per patient’s symptoms
Download the Product Leaflet, to see the details on Dose and Method of Administration of Cilacar.
Advanced aortic stenosis, Hypersensitivity to Cilnidipine or other calcium channel antagonists.
Download the Product Leaflet, to see the details on Contraindications of Cilacar.
Warnings and Precautions
Cilnidipine should be used carefully in patients with Angina, Chronic renal insufficiency, Congestive heart failure, Hypotension, Liver dysfunction, or elevated liver enzymes and Peripheral edema (confounding physical findings in congestive failure)
Download the Product Leaflet, to see the details on Warnings and Precautions of Cilacar.
Cilnidipine Drug Interactions
Cilnidipine can interact with aldesleukin, quinidine, phenytoin, rifampicin, erythromycin, other anti-hypertensive drugs and anti-psychotic drug.
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Dizziness, headache, peripheral edema, flushing, rash and gingival hyperplasia are the most common adverse events seen with the dihydropyridine derivative calcium channel antagonists. Headache, Flushing was reported in 3.7 & 4.5% of 764 subjects receiving cilnidipine respectively
Download the Product Leaflet,to see the details on adverse reactions of Cilacar.
Cilnidipine Side effects/ Overdose
Download the Product Leaflet, to see the details on Undesirable Side effects/ Overdose of Cilacar.
Pharmacodynamic and Pharmacokinetic Properties
Download the Product Leaflet, to see the details on Pharmacodynamic and Pharmacokinetic Properties of Cilacar.