Handles the pressure whatever the level
For Hypertensive patients, SBP 160mm Hg

Powered with World class OROS Technology
Laser Drilled Orifice
Nifedipine layer
Osmotic polymer pump
Fixed quantum of Nifedipine is released at a fixed interval

Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic.

Resistant hypertension was associated with an adjusted hazard ratio2 of

1.44 for coronary artery disease

1.57 for stroke

1.95 for end-stage kidney disease (ESKD)

1.30 for all-cause mortality

1.88 for heart failure

Clinical characteristic of RH patients

Older Age

Obesity

Diabetes

Chronic Kidney Diseases

High baseline Blood Pressure

Benefits of

Greater Anti-hypertensive action than Amlodipine3
Less Chances of Pedal Oedema4
Low Dialyzable5

Efficacy

Nicardia Retard Formulation

Blunted peak concentration

Twice/Thrice daily dosing

Nicardia XL OROS Formulation

Allows 24hr slow and sustained release of drug

Once daily dosing

Dosage of

NICARDIA XL 30

NICARDIA XL 60

  • Initial dose: 30 to 60 mg orally once a day.
  • Maintenance dose: 30 to 90 mg orally once a day.
  • Maximum dose: Upto 120 mg/day.

Know about Nicardia

References

1) Bharatia, R., Chitale, M., et. al Management Practices in Indian Patients with Uncontrolled Hypertension. The Journal of the Association of Physicians of India, 64(7), 14–21.
2) Pathan MK, Cohen DL. Resistant Hypertension: Where are We Now and Where Do We Go from Here?. Integr Blood Press Control. 2020;13:83-93. Published 2020 Aug 5. doi:10.2147/IBPC.S223334
3) AHA scientific statement on September 13, 2018
4) J Hypertens Suppl. 1994 Nov; 12(8) S97-10
5) Br J Clin Pharmacol. 1985 Aug; 20(2): 155–158


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