Case of 38 year old obese non-diabetic patient with Premature ASCVD
Patient Profile and history:-

A 38-year-old male businessman with active lifestyle came up with signs of sudden chest pain and giddiness. No past h/o HT/DM/IHD/HF/DKD/CKD.

ECG: ST elevation in inferior leads

2D-Echo-EF% : Mild concentric left ventricular hypertrophy (LVH), Reduced LV systolic function, LVEF 55%, Grade I LV diastolic dysfunction
Patient’s lipid profile showed elevated levels of low density lipoprotein (LDL) and triglycerides. ST elevation in inferior leads by ECG suggested inferior STEMI. 2D-Echo results suggested reduced LV systolic function.

Diagnosis: Acute Coronary Syndrome (ACS), with ST-elevation myocardial infarction (STEMI) and dyslipidemia. Patient was advised Primary Percutaneous Coronary Intervention (PCI).

Post treatment results: This was a classic case of premature ASCVD; early diagnosis and PTCA procedure was successful in removing the stenosis of Right Coronary Artery (RCA).
The Rx on discharge include an Aspirin + Atorvastatin (75/40mg) combination along with anti-platelet Ticagrelor 90mg. Patient was also on anti-hypertensive drugs which include Beta blocker.

Guideline recommendations for management of premature ASCVD: The ESC guidelines 2021, advise in established atherosclerotic disease, the use of aspirin and statin combination e.g., Ecosprin AV; this combination is associated with significant reductions in major vascular events, including stroke and coronary events, and a 10% reduction in total mortality. The benefits outweigh the bleeding hazards posed with antiplatelets.

Discussion: This is a case of real-world evidence of ASCVD management in a no-risk factor associated patient with active lifestyle. Antiplatelet combinations such as Ecosprin AV, can be prescribed as per guidelines for secondary preventions for the management of clinically significant ASCVD. The patient after 3 months of PCI and medication is able to play badminton and daily chores while taking care of his business again.

Conventional risk factors include

Hypertension

Diabetes mellitus

Dyslipidemia

Smoking

Obesity

Available SKUs

Ecosprin AV 75

Ecosprin AV 75/20

Ecosprin AV 75/40

Ecosprin AV 150

Ecosprin AV 150/20