Although they are typically safe to consume, some people may experience complications. Acid reflux, intolerance symptoms, muscle aches, and other problems are just a few of the problems tomatoes can bring on. Even the tomato plant's leaf may be dangerous. Large doses can result in nausea, headaches, dizziness, vomiting, etc. Lycopene, the same compound that, surprisingly, is responsible for its benefits as well, is another important factor that contributes to this negative aspect of tomatoes.