Medical Dialogues

HOW WELL DOES THE KETO DIET WORK TO MANAGE PCOS

Certain pathologic conditions, such as intractable epilepsy, are being treated more and more with the ketogenic diet (KD), which is hypoglycemic, high in fat, and isocaloric. Ketone bodies, which are beneficial for a variety of dysmetabolic illnesses including cardiovascular disease, are produced by KetoDiets in order to mimic a fasting state.
Keto Diet calls for a reduced carbohydrate intake of 30 to 50 grams per day along with a variety of proteins. The goal of this diet's fat intake ratios is to cause ketosis, a metabolic state in which ketone bodies created from fat serve as the main source of energy instead of glucose.
When the KD is low in calories, ketosis, higher glucagon, and decreased insulin levels have all been associated with rapid weight loss and improved metabolic profiles.
Ketosis is a powerful calorie controller that improves body weight regulation and has additional benefits that lessen IR related to obesity. Ketogenesis also increases the sensitivity of insulin receptors.
In addition, KD modifies metabolic pathways, decreasing lipogenesis while boosting fatty acid oxidation and lipolysis, ultimately affecting serum lipid levels and adipose accumulation. Additionally, KD has been linked to anti-oxidant advantages including reduced reactive oxygen species (ROS) and altered gut flora.
Body mass index (BMI), fat mass, weight, and waist circumference have all significantly decreased with the very low-calorie KD (VLCKD). The impact of ketone bodies on hunger may contribute to weight loss with VLCKD by reducing hunger and improving satiety, which leads to smaller meals and less food intake.
Patients follow either a VLCKD of 600–800 kcal per day or an LCKD, which may include more than 800 kcal per day, for the first eight to twelve weeks. The next phase involves reinstating previously prohibited foods
Starting with low glycemic index (GI) foods like dairy and fruit, then moving on to moderate GI foods like legumes, and finally high GI items like cereal, pasta, and bread. KD limits the consumption of minerals and vitamins, such as vitamin D, potassium, calcium, and magnesium, in addition to several meals.
In addition to improving body composition and lipid homeostasis, LCKD and VLKCD also cause weight loss, fat mass loss, ketone generation, reduced IR and oxidative stress, improved glucose metabolism, and improved monthly regularity and hirsutism.
The levels of circulating androgens, including free testosterone, dehydroepiandrosterone (DHEAs), anti-Müllerian hormone (AMH), luteal hormone (LH), and follicle-stimulating hormone (FSH), have also been demonstrated to be decreased by these diets. There have also been reports of increased sex hormone-binding globulin (SHBG) and enhanced ovarian function.
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