Depending on which body systems are impacted by the illness, you may experience different lupus signs and symptoms. The most common signs and symptoms are fatigue, fever, joint pain, stiffness, and swelling. Other signs and symptoms include rashes elsewhere on the body, a butterfly-shaped rash on the face covering the cheeks and bridge, skin lesions that appear or worsen with sun exposure, white or blue fingers and toes that appear when exposed to cold or under stressful circumstances, shortness of breath, chest pain, dry eyes, headaches, confusion, and memory loss.