CONCOR® (bisoprolol)
Scientific education for Registered Medical Practitioners. Please refer to full prescribing information before prescribing.
About CONCOR
Original bisoprolol brand from Merck, positioned for long-term cardiovascular management in appropriate patients.
Hypertension • Coronary heart disease (angina pectoris) • Stable chronic heart failure
Simple, practical dosing approach designed for routine clinical use.
Morning dosing • With or without food • Swallow with liquid • Do not chew
Why CONCOR
Premium scientific positioning built around cardioselectivity, predictable dosing pathways, and practical real-world use.
- Cardioselective β1-blockade
- Clear dosing range for hypertension and angina
- Structured titration schedule for stable chronic heart failure
- Convenient once-daily administration
Major Landmark trials of Bisoprolol were performed with Concor® / Concor® COR
- CIBIS II (Concor® COR)*
- TIBBS, CREATIVE (Concor®)*
Clinical evidence
Expandable evidence blocks for outcomes, 24-hour control, and practical endpoints (populate with brand-approved references).
Long-term cardioprotection outcomes
- Position: evidence-led use across cardiovascular indications where β-blockade is appropriate.
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24-hour heart rate and blood pressure control
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Dosing and titration
Hypertension or angina pectoris
- Usual initial dose: 5 mg once daily
- If necessary, increase to 10 mg once daily
- Maximum recommended dose: 20 mg once daily
Stable chronic heart failure
- Start: 1.25 mg once daily
- Stepwise increase to 2.5 mg, 3.75 mg, 5 mg, 7.5 mg, 10 mg once daily
- Intervals: two weeks or longer, as tolerated
Renal or hepatic impairment
- In severe renal impairment (creatinine clearance less than 20 ml per minute) or severe hepatic impairment, daily dose of 10 mg must not be exceeded
Safety
For professional use only. Review contraindications and warnings before prescribing.
Contraindications (summary)
- Acute heart failure or decompensation requiring intravenous inotropic therapy
- Cardiogenic shock
- Second or third degree AV block without a pacemaker
- Sick sinus syndrome, sinoatrial block
- Symptomatic bradycardia, symptomatic hypotension
- Severe bronchial asthma
- Severe peripheral arterial occlusive disease or Raynaud’s syndrome
- Untreated phaeochromocytoma
- Metabolic acidosis
- Hypersensitivity to bisoprolol or any excipients
Overdose indicators
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Cardioselective β1-blockade: practical relevance
Dosing and titration: stepwise approach
Safety overview: clinical checks and contraindications
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disease & BP
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