D-Rise

The absorption efficiency of vitamin D3 in D-rise is found up to 99 %8,9



D- Rise is made with Arachis oil (Peanut oil), the Vitamin D carrier, which is directed through passive diffusion.


Available Formula of D-Rise

60,000 IU Capsules

60,000 IU Sachet

2,000 IU Capsules

Vitamin D plays a pivotal role in promoting innate immune response and it can potentially contribute to the treatment of:

Diabetes

Type 2 Diabetes Mellitus2

COVID-19

COVID-19 3

Respiratory

Respiratory tract infections4

Heart Failure

Heart Failure 5

Stroke

Stroke5

Atherosclerosis5

Absorption7

Vitamin D undergoes two conversion steps before reaching the biologically active form. The first step is conversion to calcidiol, or 25(OH)D, in the liver. The second is conversion to calcitriol, or 1,25(OH)2D, which occurs in the kidneys, the immune system, and elsewhere. Calcitriol is the active, steroid-hormone form of vitamin D, which binds with vitamin D receptors found in most cells in the body. Vitamin is known to have multiple functions, including an important role in the immune system.


Vitamin D in COVID-19

Vitamin D supplementation helps in viral clearance of SARS CoV-2 infections3

Evidences from Indian Study

Shade study points that high dose Vitamin D supplementation is associated with3



  • Greater proportion of RNA negative
  • Significant decline in fibrinogen
  • Safe- No incident of hypercalcemia.

Vitamin D reduces the inflammatory markers associated with COVID-19 without any side effects.17

Another randomized study highlights that low Vitamin D level is an independent risk factor for

  • Acquiring COVID-19 infection
  • Hospitalization
  • COVID-19 related mortality

Vitamin D in Other Infections

1. Vitamin D in Diabetes2

Vitamin D regulates insulin sensitivity
Vitamin D:
  • Stimulates the expression of insulin receptors
  • Promotes the expression of peroxisome proliferator-activated receptor (PPAR) delta
  • Regulates the function of calbindin
  • Restores glucose-stimulated insulin secretion and promotes β-cell survival

2. Vitamin D in Cardiovascular Disease5

Vitamin D reduces the risk of CVD such as coronary artery disease (CAD), myocardial infarction (MI), hypertrophy, cardiomyopathy, fibrosis, heart failure (HF). The several Cardiovascular effects of Vitamin D includes:
  • Anti-hypertrophic properties.
  • Inhibition of cardiomyocyte proliferation.
  • Stimulation of vascular smooth muscle cell proliferation.
  • Expression of vascular endothelial growth factor.
  • Inhibition of both the renin–angiotensin–aldosterone system (RAAS)
  • Natriuretic peptide secretion.

3. Vitamin D in Atherosclerosis

Vitamin D has a protective effect on the endothelial cells by reducing endoplasmic reticulum stress and oxidative stress thereby reducing the risk of atherosclerosis.

4. Vitamin in Heart Failure

Vitamin D reduces inflammatory cytokines, such as TNF-a, interleukin (IL)-6, and IL-1beta (IL-1b), which are known to be involved in mediating Heart Failure.

5. Vitamin in Respiratory Tract Infection

Various reasons for the protective action of vitamin D in prevention of respiratory tract infections includes:

  • Vitamin D increases the production of natural antibodies.
  • Vitamin D strengthen the immunity by inducing monocyte differentiation and inhibiting lymphocyte proliferation
  • Vitamin D enhances the phagocytic activity of macrophages

Dosage

Duration Dosage
8 weeks 60,000 IU daily
As maintenance dose 2,000 IU Daily
Serum Vitamin D level to be checked after 8-12 weeks post supplementation with D.

Maintenance Dose in COVID-1918

Indications Dosage
Prevention 4000 IU for 45 days
Treatment 4000 IU per day in OPD patients for 45 days

References

1. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res. 2014;114(2):379-393. doi:10.1161/CIRCRESAHA.113.301241 2. Nakashima, A., Yokoyama, K., Yokoo, T., & Urashima, M. (2016). Role of vitamin D in diabetes mellitus and chronic kidney disease. World journal of diabetes, 7(5), 89–100. https://doi.org/10.4239/wjd.v7.i5.89 3. Rastogi A, Bhansali A, Khare N, et al Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study) Postgraduate Medical Journal 2022;98:87-90. 4. Jolliffe, D. A., Camargo, C. A., Jr, Sluyter, J. D., Aglipay, M., Aloia, J. F., Ganmaa, D., (2020). Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials. medRxiv : the preprint server for health sciences, 2020.07.14.20152728. https://doi.org/10.1101/2020.07.14.20152728 5. Rai, V., & Agrawal, D. K. (2017). Role of Vitamin D in Cardiovascular Diseases. Endocrinology and metabolism clinics of North America, 46(4), 1039–1059. https://doi.org/10.1016/j.ecl.2017.07.009 6. Rosas-Peralta, M., Holick, M. F., Borrayo-Sánchez, G., Madrid-Miller, A., Ramírez-Árias, E., & Arizmendi-Uribe, E. (2017). Dysfunctional immunometabolic effects of vitamin D deficiency, increased cardiometabolic risk. Potential epidemiological alert in America?. https://doi.org/10.1016/j.endinu.2016.11.009 7. Vitamin D for COVID-19: real-time meta analysis of 102 studies Covid Analysis, Sep 6, 2021, Version 85 — added Soliman (V1 Dec 17, 2020) https://vdmeta.com/ 8. Grossmann, R. E., & Tangpricha, V. (2010). Evaluation of vehicle substances on vitamin D bioavailability: a systematic review. Molecular nutrition & food research, 54(8), 1055–1061. https://doi.org/10.1002/mnfr.200900578 9. Critical Reviews in Food Science and Nutrition (2013): Vitamin D bioavailability: State of the art,. 10. Sun, X., Cao, Z. B., Tanisawa, K., Ito, T., Oshima, S., & Higuchi, M. (2016). Vitamin D supplementation reduces insulin resistance in Japanese adults: a secondary analysis of a double-blind, randomized, placebo-controlled trial. Nutrition research (New York, N.Y.), 36(10), 1121–1129. https://doi.org/10.1016/j.nutres.2016.07.006 11. Wang C. (2013). Role of vitamin d in cardiometabolic diseases. Journal of diabetes research, 2013, 243934. https://doi.org/10.1155/2013/243934 12. Khayznikov, M., Hemachrandra, K., Pandit, R., Kumar, A., Wang, P., & Glueck, C. J. (2015). Statin Intolerance Because of Myalgia, Myositis, Myopathy, or Myonecrosis Can in Most Cases be Safely Resolved by Vitamin D Supplementation. North American journal of medical sciences, 7(3), 86–93. https://doi.org/10.4103/1947-2714.153919 13. Wang, L. X., Wang, N., Xu, Q. L., Yan, W., Dong, L., & Li, B. L. (2017). Effects of vitamin D combined with pioglitazone hydrochloride on bone mineral density and bone metabolism in Type 2 diabetic nephropathy. Bioscience reports, 37(2), BSR20160544. https://doi.org/10.1042/BSR20160544 14. Amin, S. N., Hussein, U. K., Yassa, H. D., Hassan, S. S., & Rashed, L. A. (2018). Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats. Journal of cellular physiology, 233(8), 5768–5779. https://doi.org/10.1002/jcp.26300 15. Efficacy of Vitamin D3 in Patients With Diabetic Nephropathy: An Updated Meta-Analysis Min Zhang, Tiejun Liu, Wenge Li, Weijun Gong, Xusheng Yang, and Jianing Xi. 2017 16. Lancet Diabetes Endocrinol 2021; 9: 837–46 17. Lakkireddy, M., Gadiga, S.G., Malathi, R.D. et al. RETRACTED ARTICLE: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease. Sci Rep 11, 10641 (2021). https://doi.org/10.1038/s41598-021-90189-4 18. Bleizgys A. (2021). Vitamin D and COVID-19: It is time to act. International journal of clinical practice, 75(3), e13748. https://doi.org/10.1111/ijcp.13748 19. G, R., & Gupta, A. (2014). Vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients, 6(2), 729–775. https://doi.org/10.3390/nu6020729

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