Cilacar (Cilnidipine): Uses, Side Effects, Dosage

India's Number #1 Calcium Channel Blocker Brand^*

About CILACAR 5/10/20 mg tablets

CILACAR (Cilnidipine) is a 4^th Generation Dihydropyridine (DHP) calcium channel blocker. It is used for the treatment of Hypertension.

Cilacar is marketed by J. B. Chemicals & Pharmaceuticals Ltd. and comes in three doses namely CILACAR 5 mg, CILACAR 10 mg, CILACAR 20mg.

Cilnidipine is a 4^th Generation Dihydropyridine (DHP) calcium antagonist with a slow onset and long duration of action. Calcium antagonist inhibit influx of extracellular calcium ions into the cells, resulting in decreased vascular smooth muscle tone and vasodilation, leading to a reduction in blood pressure.

In human studies, Cilnidipine had weak inotropic effects and suppressed cardiac sympathetic overactivity. Therefore, it may decrease the risk and mortality from long term cardiovascular complications. Once-daily Cilnidipine was associated with less reflex tachycardia and had fewer effects on the autonomic nervous system in hypertensive patients (see Product Leaflet).

Reduces Arterial Stiffness and Lowers Central Aortic BP¹

As efficacious as Amlodipine with better tolerability in hypertensive patients³

Significantly reduces albuminuria in diabetic
hypertensives⁴

Offers Smooth Reduction of Blood Pressure with Less Chances of Hypotension^5,⁶

As efficacious as Amlodipine with better tolerability in Patients with hypertension⁷

Reduction inHR by 3 beats/min⁸

Minimal incidence of pedal oedema⁹

Reduction in uric acid⁸

Safe and Effective in Reducing low-grade Albuminuria in Hypertension CKD Patients¹⁰

Equal efficacy compared to Amlodipine in BP reduction¹¹

Suppresses glomerular
hypertension¹²

Effective Management of Hypertension with Elevated HR

Sustained BP Control With Neuroprotective Effects

BP variability is least with Cilnidipine compared to other CCBs¹⁷

Regresses c-IMT & reduces IAD in post - stroke hypertensive patients¹⁸

Latest Updates Section

BP Variability, Arterial stiffness and Cilnidipine – A focus review

Dr Ashwani Mehta12 Oct 2021 3:58 PM

As long back as 2600 BCE, that the Chinese Yellow emperors classic of Internal Medicine noted that if too much salt is used in blood..

Hypertension and Kidney: Choosing the Right Therapeutic Agent for BP Control and Nephroprotection

Dr. Arun Shah11 Nov 2020 3:58 PM

In the management of hypertension, the treatment goals need to be dual with equal emphasis..

Hypertension in Diabetes: Considering Therapies which Optimise Kidney Protection

Dr. Sujoy Ghosh20 Nov 2020 3:58 PM

Hypertension and Diabetes remain the top two causes of End-Stage Renal Disease (ESRD) (1)..

Combination Therapy in Hypertension with Diabetes: Preferential Consideration for CCB and ARBs

Dr. Pramila Kalra4 Jun 2021 3:58 PM

The last edition of the International Diabetes Federation (IDF) Atlas offered projections that continue to put India..

Cilacar JOURNAL UPDATE

• The Effects of the L/N-Type Calcium Channel Blocker (Cilnidipine) on Sympathetic Hyperactive Morning Hypertension: Results From ACHIEVE-ONE*

• Effects of Cilnidipine on Heart Rate and Uric Acid Metabolism in Patients With Essential Hypertension

• An Open Label Parallel Group Study to Assess the Effects of Amlodipine and Cilnidipine on Pulse Wave Velocity and Augmentation Pressures in Mild to Moderate Essential Hypertensive Patients

• Blood pressure control with cilnidipine treatment in Japanese post-stroke hypertensive patients: The CA-ATTEND study

• Evaluation of the Differences in the Effects of Antihypertensive Drugs on Blood Pressure Variability by 24-Hour Ambulatory Blood Pressure Monitoring in Chronic Cerebrovascular Disease

Overview

Name of Product : Cilacar 5mg/10mg/20mg

Manufacturer : J.B. Chemicals & Pharmaceuticals Ltd.

Medicine composition: Cilnidipine

Prescription vs.OTC: Prescription by Doctor required

Dosage Form: Tablets

Download the Product Leaflet, to see the details on Overview of Cilacar.

Indications of Cilacar

Cilnidipine is used for the treatment of mild to moderate hypertension.

Download the Product Leaflet, to see the details on Indications of Cilacar.

Cilnidipine Dose and Method of Administration

The recommended adult oral dosage of Cilnidipine is 5-10 mg once daily. The dosage can be increased up to 20 mg, if needed. Starting dose 5 to 10 mg per day depending on individual case. Maintaining dose- physician will titrate the dose as per patient’s symptoms.

Download the Product Leaflet, to see the details on Dose and Method of Administration of Cilacar.

Contraindications

Advanced aortic stenosis, Hypersensitivity to Cilnidipine or other calcium channel antagonists.

Download the Product Leaflet, to see the details on Contraindications of Cilacar.

Warnings and Precautions

Cilnidipine should be used carefully in patients with Angina, Chronic renal insufficiency, Congestive heart failure, Hypotension, Liver dysfunction, or elevated liver enzymes and Peripheral edema (confounding physical findings in congestive failure).

Download the Product Leaflet, to see the details on Warnings and Precautions of Cilacar.

Cilnidipine Drug Interactions

Cilnidipine can interact with aldesleukin, quinidine, phenytoin, rifampicin, erythromycin, other anti-hypertensive drugs and anti-psychotic drug.

Download the Product Leaflet, to see the detailed drug interactions.

Adverse Reactions

Dizziness, headache, peripheral edema, flushing, rash and gingival hyperplasia are the most common adverse events seen with the dihydropyridine derivative calcium channel antagonists. Headache, Flushing was reported in 3.7 & 4.5% of 764 subjects receiving cilnidipine respectively.

Download the Product Leaflet,to see the details on adverse reactions of Cilacar.

Cilnidipine Side effects/ Overdose

Download the Product Leaflet, to see the details on Undesirable Side effects/ Overdose of Cilacar.

Pharmacodynamic and Pharmacokinetic Properties

Download the Product Leaflet, to see the details on Pharmacodynamic and Pharmacokinetic Properties of Cilacar.

Contact us for further information

References

* Data on file, 1. Journal of Clinical Diagnostic Reasearch 2015 Nov, Vol-9(11):FC13-FC16. 2. J Cardiovasc Pharmacol 2004 Jan;43(1):68-73. 3. J Adv Pharm Technol Res. 2015 Apr-Jun; 6(2): 81-85. 4. Astan J Pharm Clin Res 2021; 14(1): 144-146. 5. Int J Pharm Sci Res. 3(12); 5044-5055. 6. Diálisis y Trasplante 2013; 34(1): 2-6 (DOI: 10.1016/j.dialis.2012.04.001) 7. Sch. J. App. Med. Sci., 2016; 4(8C):2884-2894. 8. Cardiol Res. 2016;7(5):167-172. 9. J Adv Pharm Technol Res. Apr-Jun;2015 6(2): 81-85. 10. Dialisis y Trasplante Volume 34, Issue 1, January-March 2013, Pages 2-6. 11. Global Journal of Research Analysis 2020; 9(1): 9-11. 12. Kidney International (2007) 72,1543-1549. 13. J Clin Hypertens (greenwich). 2013 Feb;15(2):133-42. 14. Cardiol Res. 2016;7(5):167-172. 15. Journal of Clinical and Diagnostic Research.2015 Nov,Vol-9(11):FC13-FC16. 16. Heart Vessel (2013) 28: 480-489. 17. J Adv Pharm Technol Res. 2015 Apr-Jun; 6(2): 81–85. 18. J Stroke Cerebrovasc Dis. 2015 Aug;24(8):1848-54. 19. J Atheroscler Thromb, 2018; 25: 490-504.

Disclaimer

India's Number #1 Calcium Channel Blocker Brand*

About CILACAR 5/10/20 mg tablets

Reduces Arterial Stiffness and Lowers Central Aortic BP1

As efficacious as Amlodipine with better tolerability in hypertensive patients3

Significantly reduces albuminuria in diabetic hypertensives4

Offers Smooth Reduction of Blood Pressure with Less Chances of Hypotension5,6

As efficacious as Amlodipine with better tolerability in Patients with hypertension7

Reduction inHR by 3 beats/min8

Minimal incidence of pedal oedema9

Reduction in uric acid8

Safe and Effective in Reducing low-grade Albuminuria in Hypertension CKD Patients10

Equal efficacy compared to Amlodipine in BP reduction11

Suppresses glomerular hypertension12