lobun-forte

, The Enteric uremic toxin reducer!


The gut has been identified as a Potential source of inflammation in CKD patients1, Probiotics have promising effects by altering production and absorption of uremic toxins and decreasing inflammation.

helps in

  • Rapid Reduction of Uremic Toxins in CKD patients
  • Delay the Progression of CKD from stage 3-4 to End Stage Renal Disease

, The Enteric uremic toxin reducer!

  • capsule has Probiotics NLT 45 Billion cells of a blend of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum, Bacillus coagulans.
  • Formulated by the house of Probiotic originator of 50 + yrs experience in manufacturing a variety of proprietary Probiotic products which are stable during shelf life, unaffected during Gastric transit and reach intact the label claim microbial count for colonization.

a blend of 4 Probiotics and each has a significant function as shown below

Streptococcus thermophilus

High urea utilising microbe

Bacillus coagulans

After the permeability of gut for passing of toxins

Bifidobacterium longum

Helps in removal of putrefactive bacteria

Lactobacillus acidophilus

Removes p-Cresol and indoxyl toxins



Does help like a dialyzer in CKD patients ?

Enteric Toxin Reduction Technology uses probiotics to transform GUT into Dialyser


Superiority over similar other products

USPS CF 90 AUX 90
Additional Strain Bacillus coagulans alters the permeability of gut for passing toxins Absent Absent
Storage No Cold Storage Strictly below 18 c Strictly below 18 c
Probiotic History Brand from House of Probiotics originator of 50 + yrs experience NA NA
CFU: Colony Forming Units

NLT 45 Billion CFU reaches intact the target site & multiplies for the next 10 – 12 hrs with twice daily dose helps to lower circulating toxins in CKD patients

Once a day dose of 90 Billion may not adequate in lowering toxin load round the clock as microbial count comes down- after some hours

Once a day dose of 90 Billion with Prebiotic fructooligosaccharides(FOS). Probiotics colonization does not need any Prebiotic support. Does not adequate in lowering toxin load round the clock as microbial count declines after some hours.


LOBUN range available as

Each Capsule has Streptococcus thermophilus, Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus to be taken twice daily after meals

Each Capsule has Streptococcus thermophilus, Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus to be taken thrice daily after meals


Outcomes

As evident from published clinical study2 of 45B CFU of Multispecies Probiotic

6 months clinical study in CKD 3 & 4 stage2

Urea hydrolysis in Large Intestine

hydrolysis
33% more Urea in 24 Hours

Acts at Ph > 7 and more potential than CF 90 strain


Benefits of therapy in CKD patients

Lowers Urea, Uric acid and Creatinine

Reduces systemic circulation of DMA, NDMA, p-Cresol, Indoles and Phosphate

Improves GFR & QOL

DMA : Dimethyl amine
NDMA : Nitroso dimethyl amine
GFR : Glomerular Filtration Rate
QOL : Quality of Life

References:

1. Lau WL, Kalantar-Zadeh K, Vaziri ND. The Gut as a Source of Inflammation in Chronic Kidney Disease. Nephron. 2015;130(2):92-8.
2. Adv Ther 2010 Sep;27(9):634-47.