Add on esketamine to propofol sedation may reduce hypotension in patients undergoing same-visit bidirectional endoscopy
A recent double-blind, placebo-controlled randomized clinical trial conducted across three teaching hospitals in China evaluated the efficacy of low-dose esketamine as an adjuvant to propofol-based sedation during same-visit bidirectional endoscopy. The study aimed to explore whether the addition of esketamine could potentially reduce the occurrence of adverse events such as desaturation and hypotension.
This study was published in the journal JAMA Network Open by Nan Song and colleagues. The trial enrolled 663 patients scheduled for same-visit bidirectional endoscopy and randomized them to receive either esketamine or a placebo. After initial sedation induction with sufentanil and propofol, the esketamine group received intravenous esketamine while the placebo group received an equivalent volume of saline. The primary outcome assessed was the composite of desaturation and hypotension during the procedures.
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