Can Mycobacterium indicus pranii improve outcomes of Sepsis patients?
Recently published paper investigates the effectiveness of Mycobacteria indicus pranii (MIP) in enhancing clinical outcomes in sepsis patients. Sepsis is a major health concern, particularly in India. The authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) focusing on 28-day mortality as the primary outcome and several secondary outcomes like ICU stay duration, days on vasopressor support, ventilator-associated pneumonia (VAP), secondary infections, and delta sequential organ failure assessment (SOFA) score. The dysregulated host immune response in sepsis and the influence of factors such as pre-morbid conditions and prompt therapeutic interventions are highlighted.
The paper explains that immunomodulatory agents like MIP are potential solutions to counteract the immunosuppressive state caused by sepsis. It details the pathways activated by lipopolysaccharide and the potential of immunomodulatory agents to counteract the immunosuppressive state caused by sepsis. The authors mention that previous studies have shown a significant decrease in mortality, fewer days on mechanical ventilation, and reduced hospital and ICU stay duration with MIP.
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