Chemotherapy in colorectal cancer does not affect depth of anesthesia with propofol: Study
Korea: Preoperative chemotherapy treatment does not affect the effect-site concentration (Ce) of propofol for loss of consciousness (LOC) and loss of verbal contact (LVC) in colorectal cancer patients, show results from a recent study. The study is published in the Korean Journal of Anesthesiology.
In surgical prognosis, the depth of anesthesia plays an important role. The sensitivity to anesthetics is affected by the neurotoxic effect of chemotherapeutic drugs.
In the new study, Seunghee Ki, Departments of Anesthesiology and Pain Medicine, Inje University College of Medicine, Busan, Korea, and colleagues aimed to determine if the effect-site concentration (Ce) of propofol for loss of consciousness (LOC) differs in patients with preoperative chemotherapy treatment.
The study included 60 patients scheduled for colorectal cancer surgery under general anesthesia. The patients were divided into two groups -- those who had chemotherapy were the experimental (C) group, and those without prior history of chemotherapy were the control (N) group.
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