Epidural Analgesia not related to Autism Spectrum Disorder: JAMA

In a study led by Anders Pretzmann Mikkelse and colleagues, it was discovered that epidural analgesia during delivery was not related with autistic spectrum condition in children. This study was done to validate a recent cohort research, epidural analgesia during delivery was linked to an elevated incidence of autism in kids.

The goal of this study was to see if having a labour epidural increased the chance of autism in the kids. The findings of this study were published in Journal of the American Medical Association on 28th September, 2021.

Between January 2006 and December 2013, all live-born children in Denmark were included in this countrywide retrospective cohort research. The follow-up began on the first birthday of the children and finished in December 2017. Among the 485 093 live-born children, 5915 were removed due to events during the first year of life such as death, emigration, birth misregistration, diagnosis of illness intrinsically related to autism, or autism diagnosis. Cox regression was used to calculate the hazard ratios, which were adjusted for variables such as maternal comorbidity, sociodemographic characteristics, lifestyle, pregnancy, mental disease, psychotropic medication, medical-seeking behaviour, and a family history of autism. In a supplementary study, a within-mother design was utilized to include only children of mothers who had both exposure and non-exposure to labour epidural analgesia in different births.