Meta analysis Compares Goal-Directed Fluid Therapy with Conventional Fluid Therapy in Neurosurgical Patients
The research published recently compared the impact of goal-directed fluid therapy (GDFT) and conventional fluid therapy on various perioperative outcomes in neurosurgical patients. The meta-analysis includes ten randomized controlled trials and evaluates neurological outcomes, postoperative complications, ICU and hospital stay, and pulmonary complications. The results indicate that GDFT did not influence neurological outcomes but significantly reduced postoperative complications, ICU and hospital stay, and pulmonary complications. Additionally, the study found that the amount of intraoperative fluids administered and blood loss were comparable between the GDFT and conventional therapy groups.
Comparison between GDFT and Conventional Fluid Therapy
The meta-analysis report observed no statistically significant difference in neurological outcomes between GDFT and conventional fluid therapy. However, GDFT significantly reduced postoperative complications, intensive care unit (ICU) and hospital stay, and pulmonary complications. The study found that the total amount of intraoperative fluids administered and blood loss were similar between the GDFT and conventional therapy groups. Additionally, sensitivity analysis was conducted for outcomes, and it was found that the neurological outcome was not affected by considering only studies with low risk of bias. Similarly, the sensitivity analysis for overall and pulmonary complications also showed that the results were stable when omitting studies with high risk of bias.
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