Oral midazolam and intranasal dexmedetomidine combo effective for managing dental anxiety in kids

Results

The rate of successful sedation was significantly higher in combination group (P = 0.007), although the sedation onset time was significantly longer in combination group (17.5 ± 2.4 min) than in monotherapy group (15.7 ± 1.8) (P = 0.003). No children required medical intervention or oxygen therapy for hemodynamic disturbances, and the incidences of adverse events had no significant difference between groups (P = 0.660).

Combined treatment with oral midazolam (0.5 mg/kg) and intranasal dexmedetomidine (2 µg/kg) is more significantly effective for managing the behavior of non-cooperative children during dental treatment, compared to oral midazolam (0.5 mg/kg) alone. (Chinese Clinical Trial Registry: ChiCTR2100042300)

Reference:

Nie, J., Chen, C., Xie, J. et al. Oral midazolam vs. intranasal dexmedetomidine plus oral midazolam for sedation of pediatric outpatients: a double-blinded randomized controlled trial. BMC Anesthesiol 23, 341 (2023). https://doi.org/10.1186/s12871-023-02289-5

Keywords:

BMC Anesthesiology, Nie, J., Chen, C., Xie, J, Dental anxiety, Midazolam, Dexmedetomidine, Sedation, Pediatric dentistry