Oral tranexamic acid at par with IV TXA for preventing blood loss after joint surgery: Study
USA: Oral tranexamic acid (TXA) is equally effective as intravenous (IV) TXA for the prevention of blood loss in total knee and total hip replacement surgery, suggest interim results from a study. The findings of the study were presented at the 2021 Spring American Society of Regional Anesthesia and Pain Medicine (ASRA) Annual Meeting.
Previously suggests that oral, IV and topical TXA are all effective at reducing blood loss and drastically reducing blood transfusion rates during and after surgery, but research with direct comparisons for each method is limited.
"TXA in orthopedic surgery has become the standard of care. However, the most efficient, efficacious, and cost-effective method of administration remains unknown," said principal investigator Stavros Memtsoudis, an anesthesiologist at HSS. "The oral administration of TXA is logistically easier, thus reducing the risk of drug errors in the OR. It is also less costly. We are performing this study to identify if oral TXA is also equally efficacious at preventing blood loss. If this is the case, oral administration of the drug preoperatively as a one-time dose could become the standard of care."
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