Remimazolam safe for induction of GA during carotid endarterectomy in elderly population

Results

SrO2 increased significantly in both groups after induction of anesthesia compared with baseline (P < 0.05) and decreased after loss of consciousness (P < 0.05).

There was no difference in the mean value of the relative changes in SrO2 between the groups. Meanwhile, the Vm, RI, HR and CI of each time point between two groups showed no statistically significant difference (P > 0.05) while MAP in group P at T5 was lower than that in group R individually(P < 0.05). In each group, Vm, HR, CI and MAP at T2-T5 were all significantly reduced compared with T1, with statistically differences(P < 0.05). Specifically, there was no difference of RI at each time between or within groups(P > 0.05).

The study revealed that remimazolam can be administered safely and effectively during the induction of general anesthesia for carotid endarterectomy in elder population and it demonstrated superiority in hemodynamic changes compared with propofol.

Reference:

Gao, J., Yang, C., Ji, Q. et al. Effect of remimazolam versus propofol for the induction of general anesthesia on cerebral blood flow and oxygen saturation in elderly patients undergoing carotid endarterectomy. BMC Anesthesiol 23, 153 (2023). https://doi.org/10.1186/s12871-023-02095-z

Keywords:

Gao, J., Yang, C., Ji, Q. , BMC Anesthesiology, Remimazolam, Propofol, Anesthesia induction, Cerebral oxygen saturation, Carotid endarterectomy