What are Alternatives to Using Midazolam as Anaesthetic Premedication in Children?
Recently published paper explores the use of midazolam as a premedication in pediatric surgery, discussing its benefits in reducing preoperative anxiety and its potential adverse effects. It highlights the prevalence of preoperative anxiety in pediatric patients and emphasizes the importance of addressing it to improve outcomes. The paper presents both pharmacological and non-pharmacological options for preoperative anxiety treatment, discussing the efficacy of midazolam, its side effects, and the potential long-term neurodevelopmental impact of prolonged exposure to benzodiazepines.
Pharmacokinetics and Effects of Midazolam
The authors review the pharmacokinetics and effects of midazolam, including its mode of action, dosing, and potential side effects such as respiratory depression and paradoxical reactions. They acknowledge the strong anxiolytic and sedative effects of midazolam, which have been widely used in pediatric surgery but also raise concerns about potential neurodevelopmental changes and the FDA warning labels for anesthetic drugs in children under three years of age.
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