Case of reverse takotsubo Cardiomyopathy caused by cryptogenic stroke- A report

This is a very rare case of PFO-related cryptogenic stroke resulting in rTTC in a teenage girl. Neurological disorders especially stroke and subarachnoid haemorrhage have been linked with the trigger of TTC. TTC is part of a broad spectrum of cardiac alterations that may occur during the first few days after occurrence of acute brain disease. A previous study demonstrated that TTC occurs secondary to stroke in 1% of patients. The rTTC, an atypical type of TTC, occurs in 2.2% of all TTC cases.

The higher frequency of adrenoreceptors in the basal left ventricular wall (compared to the apical segment) in this age bracket is thought to be one of the main reasons for the higher prevalence of rTTC in younger individuals.

Patent foramen ovale-related stroke is a rare condition, but it has been suggested that this condition may be a more important contributor to strokes in younger patients. Appropriate patient selection for PFO closure through a comprehensive stroke workup with brain–heart team is crucial in order to offer the procedure to the patients who will benefit the most and avoid unnecessary procedures especially in the younger patient (age < 18 years old).

Source: Hiroya Takafuji, Junya Arai, Kuniyasu Saigusa, Kotaro Obunai, Reverse takotsubo cardiomyopathy caused by patent foramen ovale-related cryptogenic stroke: a case report, EuropeanHeartJournal-Case Reports,

https://doi.org/10.1093/ehjcr/ytaa407