Abnormal mineral homeostasis linked to CVD risk in hypoparathyroidism patients
USA: A recent study published in The American Journal of Cardiology has suggested an association between abnormal mineral homeostasis and the risk of developing cardiovascular (CV) events in patients with chronic hyperparathyroidism. The findings indicate that better biochemical control could lower the risk of CV events in patients with hyperparathyroidism.
The study showed that adult patients with chronic hypoparathyroidism are likelier to have a CV event if they had a higher percentage of albumin-corrected serum calcium measurements outside the 2.00 to 2.25 mmol/L or any serum phosphate and any calcium-phosphate product measurements over the normal population range.
The cause of chronic hypoparathyroidism is insufficient production of the parathyroid hormone, an essential regulator of serum phosphate and calcium. Active vitamin D and oral calcium supplements are the traditional therapy strategies for these patients. However, it does not impact other physiologic functions of the parathyroid hormone.
The pathophysiological basis for the increased risk of CVD (cardiovascular disease) in patients with chronic hypoparathyroidism is poorly understood. Therefore, Sanjiv Kaul, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, and colleagues aimed to evaluate the association between levels of serum phosphate, albumin-corrected serum calcium, and calcium-phosphate product with the odds of developing CV (cardiovascular events) in patients with chronic hypoparathyroidism with ≥1 calcitriol prescription.
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