AF recurrence after non cardiac surgery tied to risk of bleeding and death: Study
South Korea: Atrial fibrillation (AF) recurs after noncardiac surgery in 16.8% of postoperative atrial fibrillation (POAF) patients, finds a recent study in the Journal of the American Heart Association. AF recurrence was associated with higher risks of major bleeding and thromboembolic events.
"Routine anticoagulation in POAF should be carefully determined in these patients, considering the the relatively low risk for thromboembolic events and a high risk of anticoagulation‐related bleeding," wrote the authors.
POAF is a common occurrence after cardiac surgery, but not much is known about its incidence and natural course following noncardiac surgery. Therefore, Gi‐Byoung Nam, University of Ulan College of Medicine, Seoul, South Korea, and colleagues aimed to evaluate natural course and clinical impact of POAF and the long‐term impact of anticoagulation therapy in patients without a history of atrial fibrillation undergoing noncardiac surgery.
For the purpose, the researchers retrospectively analyzed the database of Asan Medical Center (Seoul, Korea) to identify patients who developed new‐onset POAF after undergoing noncardiac surgery between January 2006 and January 2016. The main outcomes were AF recurrence, thromboembolic event, and major bleeding during follow‐up.
Key findings of the study include:
- Of 322 688 patients who underwent noncardiac surgery, 315 patients (mean age, 66.4 years; 64.4% male) had new‐onset POAF with regular rhythm monitoring after discharge. AF recurred in 53 (16.8%) during 2 years of follow‐up.
- Hypertension (hazard ratio, 2.12), moderate‐to‐severe left atrial enlargement (hazard ratio, 2.33) were independently associated with recurrence.
- Patients with recurrent AF had higher risks of thromboembolic events (11.2% versus 0.8%) and major bleeding (26.9% versus 4.1%) than those without recurrence.
- Patients with recurrent AF and without anticoagulation were especially predisposed to thromboembolic events.
- Anticoagulation therapy was not significantly associated with thromboembolic events (1.4% versus 2.5%).
"AF recurred in 16.8% of patients with POAF after noncardiac surgery. AF recurrence was associated with higher risks of adverse clinical outcomes," wrote the authors. "Considering the high risk of anticoagulation‐related bleeding, the benefits of routine anticoagulation should be carefully weighed in this population. Active surveillance for AF recurrence is warranted."
Reference:
The study titled, "Natural Course of New‐Onset Postoperative Atrial Fibrillation after Noncardiac Surgery," is published in the Journal of the American Heart Association.
DOI: https://www.ahajournals.org/doi/10.1161/JAHA.120.018548
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