Alpha blockers may be new treatment option for salt sensitive hypertension: Study

The researchers used an experimental model that was fed a high salt diet (to model the content of a western diet) which led to an increase in their blood pressure. A portion of these models were then treated with an alpha 1 adrenoceptor blocker that reduced their blood pressure by decreasing the activity of a pathway in the kidney that reabsorbs salt. "Our data suggest blocking renal α1-adrenoceptors may represent a new treatment approach for patients with salt sensitive hypertension," said corresponding author Richard Wainford, PhD, associate professor of Pharmacology & Experimental Therapeutics at BUSM.

According to the researcher this study highlights the critical role of looking at the disease of hypertension in an integrated way by examining the interaction between multiple organ systems, in this case the sympathetic nervous system and kidney versus working in isolation. "We hope that these studies, that highlight a new mechanism underlying the salt sensitivity of blood pressure, will drive new treatment approaches for hypertension."