Association of Adiposity with protein biomarkers increases CVD risk: JAMA
China: A recent study has found association between adiposity and a range of protein biomarkers that in part might explain the association between adiposity (obesity) and cardiovascular disease (CVD). The findings of the study are published in the journal JAMA Cardiology.
"For many such biomarkers, there was a consistency between genetic and observational findings in their associations with BMI. Some of the BMI-associated protein biomarkers were also shown to be observationally associated with incident CVD risk," wrote the authors.
Obesity is associated with higher CVD risk but bot much is known about the role of circulating protein biomarkers in this association. Yuanjie Pang, Peking University, Beijing, China, and colleagues therefore examined the observational and genetic associations of adiposity with circulating protein biomarkers and the observational associations of proteins with incident CVD.
The study included 628 participants from the prospective China Kadoorie Biobank who did not have cancer history at baseline. 92 protein markers in baseline plasma samples were measured via the Olink platform. The researchers collected data from June 2004 to January 2016 and analyzed from January 2019 to June 2020.
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