Atorvastatin fails to slow aortic dilatation and valvular calcification progression in bicuspid aortic valve: BICATOR Trial
Spain: In a significant stride toward managing aortic health, a recent randomized clinical trial, BICATOR (Bicuspid Aortic Valve), has uncovered findings regarding the efficacy of atorvastatin in slowing the progression of aortic dilatation and valvular calcification in individuals with bicuspid aortic valve (BAV) disease.
The study, published in Circulation, found that atorvastatin treatment failed to reduce the progression of ascending aorta dilation and aortic valve calcification in bicuspid aortic valve without severe valvular dysfunction patients during three years of treatment, despite a significant reduction in low-density lipoprotein (LDL) cholesterol levels.
BAV, a condition where the aortic valve has two leaflets instead of the typical three, affects approximately 1-2% of the population and predisposes individuals to a spectrum of cardiovascular complications, including aortic dilatation and valvular calcification. These complications often necessitate invasive interventions like valve replacement surgeries and are associated with increased morbidity and mortality.
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