Benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis: Study

According to the CDC data pulled by the researchers for this report, as of June 23, 2021, more than 177 million people in the U.S. had received at least one dose of a COVID-19 vaccine. The rates of suspected myocarditis/pericarditis were approximately 12.6 cases per million doses of the second dose of a COVID-19 mRNA vaccine among 12–39 year-olds as of June 5, 2021, according to data from the CDC's Vaccine Safety Dataline.

The researchers also conducted a prevention analysis by comparing the rate of suspected myocarditis to the prevention of COVID-19, COVID-19-associated hospitalization, COVID-19 ICU admission and COVID-19-related death. The benefit-risk assessment indicates that the benefits of the COVID-19 vaccine outweigh the risk of myocarditis. The research group concluded:

• There is a "known potential risk of complications with COVID-19 infection, including hospitalizations and death, even in younger adults (mortality remains 0.1-1 per 100,000 for persons aged 12-29 years);
• The risk-benefit decision remains overwhelmingly favorable for vaccination; therefore COVID-19 vaccination is currently recommended for everyone 12 years of age and older.
• COVID-19 vaccination not only prevents COVID-19-related hospitalizations and death, but also COVID-19 related complications such as myocarditis, multisystem inflammatory syndrome (MIS) and post-acute sequelae (i.e., consequences) of SARS-CoV-2 infection or long COVID-19."

The researchers recommend that clinicians should be aware of the potential for myocarditis and pericarditis, which should be considered in individuals presenting with chest pain within a week after receiving a COVID-19 vaccine, especially among adolescents, teens and young adults.

Further analysis of this study investigated some of the possible clinical mechanisms causing myocarditis after COVID-19 vaccination, however, the authors noted more research is needed.