Beta-blockers may reduce all-cause mortality in HFpEF patients
According to the American and European heart failure guidelines, HFpEF is defined as a condition with LVEF >=50% and accompanying signs and symptoms of heart failure, along with elevated left ventricular filling pressures, such as increased natriuretic peptide levels and hemodynamic measurements. It imposes a financial burden, affects healthcare system resource allocation, and is linked to higher morbidity and mortality rates.
According to a recently published meta-analysis, Current Problems in Cardiology, Beta-blockers can decrease all-cause mortality in individuals with heart failure with preserved ejection fraction (HFpEF). However, they did not affect cardiovascular mortality or rehospitalization.
Beta-blockers are commonly used to treat heart failure with reduced ejection fraction, but the same may not apply to HFpEF. This study aimed to evaluate beta-blockers impact on mortality and rehospitalization in HFpEF patients through a systematic review and meta-analysis. The primary outcomes were all-cause and cardiovascular mortality, all-cause and heart failure-related rehospitalization, and a composite of these endpoints.
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