Blood urea nitrogen level may predict readmissions, mortality in HFpEF patients: Study

This prospective, multicenter research recruited HFpEF (50 percent left ventricular ejection fraction) patients hospitalized owing to acute decompensated heart failure from the PURSUIT-HFpEF registry. To rule out the influence of renal function on BUN levels, propensity score matching was used with factors related to GFR. The incidence of all-cause mortality and HF readmission among patients stratified by BUN, as well as the relationship between BUN and echocardiographic parameters in HFpEF patients, were investigated.

The key findings of this study were as follows:

1. This experiment had a total of 1029 subjects.

2. In this investigation, the BUN cut-off value was 24.4 mg/dL, which was also the median value in the whole population.

3. After 1:1 propensity score matching, the high and low BUN groups each included 193 patients.

4. The average period of follow-up was 401 days, and the composite endpoint occurred in 129 individuals (33.4% ).

5. In the propensity score-matched pairings, the high BUN group had a substantially higher risk of the composite endpoint than the low group.

6. Multiple regression analyses employing echocardiographic data revealed a substantial correlation between BUN and left atrial volume index.

In conclusion, according to the findings of this study, high BUN was related to the composite of all-cause mortality and HF readmission in HFpEF.

Reference:

Yano, M., Nishino, M., Ukita, K., Kawamura, A., Nakamura, H., Matsuhiro, Y., Yasumoto, K., Tsuda, M., Okamoto, N., Matsunaga-Lee, Y., Egami, Y., Tanouchi, J., … Sakata, Y. (2022). Clinical impact of blood urea nitrogen, regardless of renal function, in heart failure with preserved ejection fraction. In International Journal of Cardiology. Elsevier BV. https://doi.org/10.1016/j.ijcard.2022.06.061