Blood urea nitrogen level may predict readmissions, mortality in HFpEF patients: Study

The key findings of this study were as follows:

1. This experiment had a total of 1029 subjects.

2. In this investigation, the BUN cut-off value was 24.4 mg/dL, which was also the median value in the whole population.

3. After 1:1 propensity score matching, the high and low BUN groups each included 193 patients.

4. The average period of follow-up was 401 days, and the composite endpoint occurred in 129 individuals (33.4% ).

5. In the propensity score-matched pairings, the high BUN group had a substantially higher risk of the composite endpoint than the low group.

6. Multiple regression analyses employing echocardiographic data revealed a substantial correlation between BUN and left atrial volume index.

In conclusion, according to the findings of this study, high BUN was related to the composite of all-cause mortality and HF readmission in HFpEF.

Reference:

Yano, M., Nishino, M., Ukita, K., Kawamura, A., Nakamura, H., Matsuhiro, Y., Yasumoto, K., Tsuda, M., Okamoto, N., Matsunaga-Lee, Y., Egami, Y., Tanouchi, J., … Sakata, Y. (2022). Clinical impact of blood urea nitrogen, regardless of renal function, in heart failure with preserved ejection fraction. In International Journal of Cardiology. Elsevier BV. https://doi.org/10.1016/j.ijcard.2022.06.061