Both High and low blood eosinophil counts predict risk of all-cause and cardiac deaths in patients with acute MI: Study
High and low blood eosinophil counts both predict the risk of all-cause and cardiac deaths in patients with acute myocardial infarction suggests a study published in the Journal of American Heart Association.
In patients with acute MI, low eosinophil counts at admission (<0.02×10⁹/L) and discharge (<0.03×10⁹/L) sharply increased 30-day all-cause and cardiac mortality risks. A synergistic effect was noted when both counts were low (OR, 13.93 for all-cause mortality | OR, 11.38 for cardiac mortality). Additionally, high eosinophil counts at discharge were independently tied to higher long-term mortality risk (HR, 1.84).
Preclinical studies demonstrate a cardioprotective role of eosinophils in acute myocardial infarction. Yet clinical studies show conflicting correlations between blood eosinophil counts and acute myocardial infarction risk and mortality.
This study evaluates blood eosinophil counts of patients with acute myocardial infarction at hospital admission (EOSbaseline) and discharge (EOSpost) on all-cause and cardiac mortalities. Of 2681 consecutive patients with a median follow-up of 2.55 years, 45 patients died within 30 days, 28 died within 30 to 150 days, and 92 died within 150 days or later postdischarge. Cardiac death occurred in 108 patients.
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