BP lowering effects of renal denervation maintained upto 1 year with fewer medicines: JACC

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-01-20 05:45 GMT | Update On 2021-01-20 08:18 GMT

Delhi: With fewer prescribed antihypertensive medications, the BP lowering effect of endovascular ultrasound renal denervation (RDN) was maintained at 12 months compared to sham, according to a recent study in the journal JACC: Cardiovascular Interventions.

Previous RCTs have shown the blood pressure (BP)–lowering efficacy and safety of endovascular ultrasound renal denervation in the absence and presence of antihypertensive medications. This study by Michel Azizi , Hypertension Department and DMU Carte, Paris, France, and colleagues reports the 12-month results of the RADIANCE-HTN (A Study of the ReCor Medical Paradise System in Clinical Hypertension) SOLO trial following unblinding of patients at 6 months.

It included patients with daytime ambulatory BP ≥135/85 mm Hg after 4 weeks off medication. They were randomized to receive RDN (n = 74) or sham (n = 72) and maintained off medication for 2 months. A standardized medication escalation protocol was instituted between 2 and 5 months (blinded phase). Between 6 and 12 months (unblinded phase), patients received antihypertensive medications at physicians' discretion.

Outcomes at 12 months included medication burden, change in daytime ambulatory systolic BP (dASBP) and office or home systolic BP (SBP), visit-to-visit variability in SBP, and safety.

Key findings of the study include:

Sixty-five of 74 RDN patients and 67 of 72 sham patients had 12-month dASBP measurements.
The proportion of patients on ≥2 medications (27.7% vs. 44.8%), the number of medications (0 vs. 1.4), and defined daily dose (1.4 vs. 2.2) were less with RDN versus sham.
The decrease in dASBP from baseline in the RDN group (−16.5 ± 12.9 mm Hg) remained stable at 12 months.
The RDN versus sham adjusted difference at 12 months was −2.3 mm Hg for dASBP, −6.3 mm Hg for office SBP, and −3.4 mm Hg for home SBP.
Visit-to-visit variability in SBP was smaller in the RDN group.
No renal artery injury was detected on computed tomographic or magnetic resonance angiography.

"The decrease in BP with a treatment strategy including RDN followed by subsequent addition of antihypertensive medications was associated with a lower VVV of BP than a treatment strategy including stepped-care intensified antihypertensive treatment only," wrote the authors.

"Despite unblinding, the BP-lowering effect of RDN was maintained at 12 months with fewer prescribed medications compared with sham." they concluded.

Article Source : JACC: Cardiovascular Interventions

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Medha Baranwal

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Worse outcomes with aspirin in high-risk chronic coronary syndrome patients who require long-term anticoagulation: ESC Study

2025-09-08 14:45 GMT

BP lowering effects of renal denervation maintained upto 1 year with fewer medicines: JACC

Similar News

Inflammation may explain why women with no standard modifiable risk factors have heart attacks and strokes: ESC Study

Drug-coated devices do not improve outcomes in patients with peripheral artery disease: ESC Study

Stay Moving: Exercise After Knee Replacement Cuts Heart and Stroke Risks, Study Suggests

Worse outcomes with aspirin in high-risk chronic coronary syndrome patients who require long-term anticoagulation: ESC Study

Women With Pre-Pregnancy Chronic Conditions Face Greater Risk of Severe Maternal Complications: Study Shows

De-escalation of DAPT provides benefits in patients after CABG: ESC Study

Abelacimab Cuts Bleeding Risk in AF Patients Regardless of Kidney Function: AZALEA-TIMI 71 Analysis

Post MI Beta blockers may offer no benefit for heart attack patients and women can have worse outcomes: ESC Study