BP lowering effects of renal denervation maintained upto 1 year with fewer medicines: JACC
Delhi: With fewer prescribed antihypertensive medications, the BP lowering effect of endovascular ultrasound renal denervation (RDN) was maintained at 12 months compared to sham, according to a recent study in the journal JACC: Cardiovascular Interventions.
Previous RCTs have shown the blood pressure (BP)–lowering efficacy and safety of endovascular ultrasound renal denervation in the absence and presence of antihypertensive medications. This study by Michel Azizi , Hypertension Department and DMU Carte, Paris, France, and colleagues reports the 12-month results of the RADIANCE-HTN (A Study of the ReCor Medical Paradise System in Clinical Hypertension) SOLO trial following unblinding of patients at 6 months.
It included patients with daytime ambulatory BP ≥135/85 mm Hg after 4 weeks off medication. They were randomized to receive RDN (n = 74) or sham (n = 72) and maintained off medication for 2 months. A standardized medication escalation protocol was instituted between 2 and 5 months (blinded phase). Between 6 and 12 months (unblinded phase), patients received antihypertensive medications at physicians' discretion.
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