Calcium supplementation with or without vitamin D tied to lower survival in aortic stenosis: Study
USA: A new study published in the British Medical Journal suggests that in older individuals with mild-moderate aortic stenosis (AS), calcium supplementation with or without vitamin D is related to lower survival and increased aortic valve replacement (AVR).
Aortic stenosis has long been linked to calcium metabolism. Studies on the long-term safety of oral calcium and/or vitamin D in AS are few, but necessary given the growing use among an elderly population prone to insufficiency. As a result, Nicholas Kassis and colleagues undertook this study to investigate the links between supplementary calcium and vitamin D and AS mortality and progression.
Patients aged 60 years with mild-moderate native AS were recruited from the Cleveland Clinic Echocardiography Database between 2008 and 2016 and monitored till 2018. The groups were divided into three categories: no supplementation, vitamin D supplementation alone, and calcium±vitamin D supplementation. The primary objectives were mortality (all-cause, CV, and non-CV), as well as aortic valve replacement; the secondary outcomes were AS progression by aortic valve area and peak/mean gradients.
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