Cardiovascular biomarkers strongly associated with fatal and nonfatal CV events and mortality: JAMA
CAPTION
Novel biomarkers predict the development of incident heart failure.
CREDIT
MostPhotos/Rossella Apostoli.
Researchers in a recent study have sought to enhance risk prediction for atherosclerotic cardiovascular disease (ASCVD) by evaluating the prognostic value of various cardiovascular biomarkers in addition to established risk factors. Identifying individuals at high risk for ASCVD is crucial for informing primary prevention strategies. However, their impact is more significant for heart failure and mortality outcomes, particularly in older adults. This study was published in JAMA by Neumann JT and colleagues.
The study included individuals with a median age of 53.1 years, of whom 52.4% were women, with a median follow-up of 11.8 years. Incidence of ASCVD events totaled 17,211 cases during the follow-up period. Each biomarker showed a significant association with ASCVD and secondary outcomes. Addition of biomarkers to established risk factor models led to a small improvement in risk prediction metrics for ASCVD but had a more pronounced impact on heart failure and mortality outcomes, particularly in individuals aged 65 years or older.
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