Chlorthalidone more effective than HCTZ in reducing MACE in long term: Study
Written By : Dr. Nandita Mohan
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2021-01-24 16:00 GMT | Update On 2021-01-25 07:29 GMT
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According to recent research, investigators from the NYU School of Medicine, New York City, New York, USA found out that over the short-term there were no differences in the net clinical benefit between hydrochlorothiazide and chlorthalidone.
The study is published in the Journal of Hypertension.
There is continuous debate whether chlorthalidone (CTD) and hydrochlorothiazide (HCTZ) differ in reducing major cardiovascular events (MACE). HCTZ is prescribed 10 times more commonly than CTD.
Hence, Roush, George C. and colleagues conducted this study to assess the difference between Chlorthalidone and hydrochlorothiazide in terms of major cardiovascular events, blood pressure, left ventricular mass, and adverse effects.
They carried out a systematic literature search which yielded 14 references, including two network meta-analyses of randomized trials with MACE and left ventricular mass as outcomes.
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