Colchicine reduces ischemic events in CAD but causes GI upset: Study
Colchicine tends to decrease risk of ischemic events in patients with coronary artery disease but increases the incidences of gastrointestinal upset, suggests a study published in the Journal of the American Heart Association.
Coronary artery disease is the buildup of plaque in the arteries that supply oxygen-rich blood to your heart. Plaque causes a narrowing or blockage that could result in a heart attack. Inflammation plays a crucial role in coronary artery disease (CAD). The anti‐inflammatory drug colchicine seems to reduce ischemic events in patients with coronary artery disease (CAD). However, not much data is available on its safety profile and impact on mortality.
A group of researchers from Switzerland conducted a systematic review and meta‐analysis to evaluate the utility of colchicine in patients with acute and chronic coronary artery disease (CAD).
The researchers searched MEDLINE, EMBASE, Cochrane CENTRAL, and conference abstracts from January 1975 to October 2020. Randomized trials assessing colchicine compared with placebo/standard therapy in patients with coronary artery disease (CAD) were included. Data were combined using random‐effects models. The reliability of the available data was tested using trial sequential analyses.
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