Coronary artery calcium associated with prevalence of diastolic dysfunction: BMC

This study was a cohort study based on the population. Every one of the 15,193 persons who had a health screening examination that included both a CAC scan and echocardiography at the same time was recruited. Both definite or probable DD (≥2/4) and definite DD (≥3/4 aberrant values for DD [e′, E/e′, tricuspid regurgitation velocity, and left atrial volume index]) were identified. Based on the CAC and DD, all-cause mortality was calculated.

Of the individuals in the population, 7995 had CAC = 0, 4661 had 0 < CAC < 100, and 2537 had CAC > 100. Those with CAC = 0 had considerably lower prevalence ratios for definite and definite or probable DD than those with CAC = 100. The linear relationship between CAC and E/e′ was significant.

The adjusted HRs with 95% CI for mortality of CAC ≥100 without definite DD, CAC <100 with definite DD, and CAC ≥100 with definite DD were 2.56, 3.08, and 3.91, respectively, in comparison to CAC <100 without definite DD. Significant CAC was substantially linked to quicker development in definite DD over time, with a faster elevation of E/e′ during follow-up among subjects with at least two echocardiographic measures who did not have DD at the time of CAC assessment.

Overall, there was a significant correlation between CAC and DD in a general population that had a thorough health screening examination that included both a CAC scan and echocardiography at the same time. The risk of mortality was higher for patients with both subclinical measures than for those with only one.

Source:

Choi, K. H., Kang, D., Lee, S. H., Kim, D., Cho, S. W., Choi, S.-H., Park, T. K., Lee, J. M., Song, Y. B., Hahn, J.-Y., Choi, S.-H., Gwon, H.-C., Cho, S. J., & Yang, J. H. (2025). Impact of coronary artery calcium on progression of diastolic dysfunction: a cohort study. BMC Medicine, 23(1). https://doi.org/10.1186/s12916-025-03956-9