Coronary microvascular dysfunction predicts cancer risk in NOCAD patients: Study
USA: Coronary microvascular dysfunction (CMD) in patients with non-obstructive coronary artery diseases (NOCAD) is linked with cancer incidence, says a recent study in the European Journal of Preventive Cardiology.
NOCAD is a less common form of coronary artery disease (CAD) that occurs when the heart's arteries are inappropriately constricted, are squeezed by the overlying heart muscle, or malfunction after branching into tiny vessels.
Previous studies have shown common pathogenesis and risk factors in cardiovascular disease and cancer. Coronary microvascular dysfunction indicating impaired coronary microvascular dilation in response to stress is tied to a higher risk of major cardiovascular events; however, no studies have been performed on establishing its association with cancer.
Considering the above, Amir Lerman, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA, and colleagues performed a retrospective study on 1042 patients with non-obstructive coronary artery diseases. They collected data on clinical history, demographic, cancer occurrence, and diagnostic coronary reactivity tests. CMD was defined as coronary flow reserve (CFR, the ratio of hyperemic blood flow to resting blood flow) ≤2.5.
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