Counts of Apolipoprotein B particles and lipoprotein A may predict coronary Heart Disease Risk: Study
A recent study published in the European Heart Journal investigated lipoproteins containing apolipoprotein B, a protein essential to transporting “bad” cholesterol. The study concluded that the counts of apolipoprotein B particles and lipoprotein(a) are crucial indicators of lipid-related risk for coronary artery disease. This study was conducted by Jakub Morze and fellow researchers.
Apolipoprotein B (apoB) is found in all atherogenic lipoproteins, including very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL). Although apoB levels are already established as an important lipid marker, this research attempted to determine whether the particular type, size, or subclass of apoB-containing particles contributes anything to the predictive value for CAD over and above the total number. The contribution of lipoprotein(a), or Lp(a)—a genetically determined lipid marker—was also evaluated for its independent contribution to cardiovascular risk.
The study examined data for 207,368 UK Biobank participants who had no history of atherosclerotic cardiovascular disease, diabetes, or active lipid-lowering treatment at baseline. The researchers employed multivariable-adjusted Cox regression models to assess the association of various lipid measures with incident CAD. These were:
• Total apoB-P levels as quantified by nuclear magnetic resonance
• Individual lipoprotein class concentrations (LDL and VLDL)
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