CTO revascularization improves total myocardial viability: Study
Netherlands: Chronic total occlusion (CTO) revascularization increases remote myocardial perfusion, a recent study has shown. The biggest gains were observed in patients having significant improvements in various blood flow measures. This indicates that "CTO percutaneous coronary intervention (PCI) may have a favorable physiologic impact beyond the intended treated myocardium," the researchers wrote. The study appears in the journal EuroIntervention.
CTO revascularization is known to impact the coronary physiology of the remote myocardial territory. Ruben W. de Winter, Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands, and colleagues aimed to evaluate the intrinsic effect of CTO PCI on changes in absolute perfusion in remote myocardium.
The study included a total of 164 patients who underwent serial [15O]H2O positron emission tomography (PET) perfusion imaging at baseline and three months after successful single-vessel CTO PCI. They were evaluated for changes in coronary flow reserve (CFR) and hyperaemic myocardial blood flow (hMBF) in remote myocardium supplied by both non-target coronary arteries.
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