Dapagliflozin reduced mortality risk in aortic stenosis patients undergoing TAVI: Study

Following TAVI, a total of 637 patients were randomly allocated to receive standard therapy alone, and 620 patients were randomly assigned to take dapagliflozin; 1222 patients were included in the primary analysis after exclusions.

Nearly, 91 patients (15.0%) in the dapagliflozin group and 124 patients (20.1%) in the standard-care group experienced a primary-outcome event. 55 patients (8.9%) in the standard-care group and 47 patients (7.8%) in the dapagliflozin group died from any cause. In 9.4% and 14.4% of the patients, respectively, heart failure worsened. The dapagliflozin group experienced a substantially higher incidence of genital infection and hypotension.

Overall, the effectiveness of dapagliflozin in the TAVI group emphasizes that these patients do not have a normal heart even when the outflow blockage has been relieved. When compared to conventional treatment alone, dapagliflozin significantly reduced the incidence of mortality from any cause and worsening of heart failure in older persons with aortic stenosis receiving TAVI who were at high risk for heart-failure events.

Source:

Raposeiras-Roubin, S., Amat-Santos, I. J., Rossello, X., González Ferreiro, R., González Bermúdez, I., Lopez Otero, D., Nombela-Franco, L., Gheorghe, L., Diez, J. L., Baladrón Zorita, C., Baz, J. A., Muñoz García, A. J., Vilalta, V., Ojeda-Pineda, S., de la Torre Hernández, J. M., Cordoba Soriano, J. G., Regueiro, A., Bordes Siscar, P., Salgado Fernández, J., … Ibáñez, B. (2025). Dapagliflozin in patients undergoing transcatheter aortic-valve implantation. The New England Journal of Medicine. https://doi.org/10.1056/nejmoa2500366