Diabetes and elevated HbA1c Increase Sudden Arrhythmic Death Risk in CAD: Study
Diabetes and elevated hemoglobin A1c (HbA1c) are associated with an increased risk of sudden and/or arrhythmic death (SAD) and other causes of death in patients with coronary artery disease (CAD) and left ventricular ejection fraction (LVEF) of more than 30% to 35%, according to study published in JACC: Clinical Electrophysiology.
Patients with coronary artery disease (CAD) and DM are at elevated risk for sudden and/or arrhythmic death (SAD); however, it is unclear whether these patients would benefit from implantable cardioverter-defibrillators has given competing causes of death and/or whether HbA1c might augment SAD risk stratification.
A group of researchers conducted a study to determine the absolute and relative associations of diabetes mellitus (DM) and hemoglobin A1c (HbA1c) with sudden and/or arrhythmic death (SAD) versus other modes of death in patients with coronary artery disease (CAD) who do not qualify for implantable cardioverter-defibrillators.
In the PRE-DETERMINE study of 5,764 patients with CAD with left ventricular ejection fraction (LVEF) of >30% to 35%, competing risk analyses were used to compare the absolute and relative risks of SAD versus non-SAD by DM status and HbA1c level and to identify risk factors for SAD among 1,782 patients with DM.
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