Diabetes and prediabetes not independent risk factors for AF
Sweden: Upon adjustment for potential confounders, a recent study found that the association between glycemic status and atrial fibrillation and atrial flutter (AF) disappears. Additionally, prediabetes and diabetes are not independent risk factors for atrial fibrillation. The study was published in the Journal of Internal Medicine on 30 June 2023.
Previous research have reported an increased risk for atrial fibrillation and atrial flutter in patients with prediabetes and type 2 diabetes. However, there is no clarity on whether this increase in AF risk is independent of other risk factors for AF. Cecilia Johansson, Department of public health and clinical medicine, Umeå University, Sweden, and colleagues aimed to investigate the association between diabetes and different prediabetic states as independent risk factors for the onset of AF.
For this purpose, the researchers performed a population-based cohort study in Northern Sweden, comprising data on oral glucose tolerance tests, fasting plasma glucose, medical history, major cardiovascular risk factors, and lifestyle factors. Participants were divided into six groups based on glycemic status and followed through national registers to diagnose atrial fibrillation and atrial flutter. The association between glycemic status and AF was assessed using Cox proportional hazard model, and normoglycemia was the reference.
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