DOACs effective alternative to Vitamin K Antagonists for LV thrombus: Study
A recent study has demonstrated no significant difference in SEE, major bleeding, or failure of LV thrombus resolution between the two groups, thus demonstrating that direct oral anticoagulants (DOACs) are an efficacious and safe alternative for the treatment of LV thrombus compared to Vitamin K Antagonists. Findings have been published in Journal of Cardiovascular Electrophysiology. .
Oral anticoagulation is effective in the prevention of ischemic stroke and systemic embolism in patients with atrial fibrillation (AF). Vitamin K antagonists (VKAs) inhibiting the production of several coagulation factors in the liver have been the only option for long‐term oral anticoagulation for many years. Direct oral anticoagulants (DOACs) including the thrombin inhibitor, dabigatran, and the factor Xa inhibitors, apixaban, edoxaban, and rivaroxaban, have been proven to be at least as effective in preventing ischemic stroke and systemic embolism in patients with AF while having a lower risk of symptomatic intracranial hemorrhage.
Though current guidelines currently recommend using warfarin, there is also a growing interest in the utilization of direct oral anticoagulants (DOACs) to treat left ventricular (LV) thrombus.
For the study design, Researchers performed a systematic search using PubMed, SCOPUS, EMBASE, Google Scholar, and ClinicalTrials.gov from inception to September 30, 2020, for studies that had reported outcomes in patients with left ventricular thrombus treated with DOACs (PROSPERO registration number CRD42020219761).
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