Double antithrombotic therapy better in reducing bleeding risk in AF patients after PCI, says study
Delhi: Double versus triple antithrombotic therapy (DAT vs. TAT) is associated with a reduction in bleeding events in patients with atrial fibrillation (AF) patients undergoing percutaneous coronary intervention (PCI), a recent study in the European Heart Journal has suggested.
According to the study, DAT, particularly if consisting of a NOAC (non-vitamin K antagonist oral anticoagulant) instead of vitamin K antagonist (VKA) and a P2Y12 inhibitor lowers the risk of bleeding, including major and intracranial hemorrhages. However, this benefit is counterbalanced by a higher risk of cardiac—mainly stent-related—but not cerebrovascular ischaemic occurrences.
Marco Valgimigli, University of Bern, Bern, Switzerland, and colleagues investigated the safety and efficacy of DAT versus TAT in patients with atrial fibrillation and acute coronary syndrome (ACS) or who underwent percutaneous coronary intervention.
For the purpose, the researchers performed a systematic review and meta-analysis using online databases to search for NOAC-based randomized clinical trials comparing DAT versus TAT in AF patients undergoing PCI. Four trials including 10 234 patients (DAT = 5496 vs. TAT = 4738) were included.
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