Exercise-induced oxidative stress predicts poor prognosis in HF patients: Study
Japan: Heart failure (HF) patients who underwent a cardiopulmonary exercise test and showed an increase in oxidative stress had a poor prognosis, show results from a recent study in the European Heart Journal: ESC heart failure. By evaluating the changes in oxidative stress status in response to acute exercise in HF patients, the appropriate exercise intensity could be determined.
"These results show that for patients with acute decompensated heart failure, any form of exercise may not be the most effective prognostic tool," suggests Atsushi Shibata, research lead and assistant professor at OCU Department of Cardiovascular Medicine, "we need to know what type of exercise and the degree of intensity that is best fit for each patient and measuring levels oxidative stress shows promise."
While exercise therapy for heart failure (HF) patients with low heart function has been shown to be an effective prognostic tool, the level and format of exercise that yields optimal effects are still unclear. Researchers from the Osaka City University (OCU) Graduate School of Medicine aimed to understand how exercise-induced oxidative stress affects patients with HF.
From July 2013 to March 2015, the study drew 94 participants from a cardiac rehabilitation program after being admitted into Osaka City University Hospital for worsening HF. Diacron-reactive oxygen metabolites (d-ROM) values, a marker of oxidative stress, were taken from patient blood samples before and after they performed a cardiopulmonary exercise test with enough exercise to make them aware of the load. The team defined d-ROM as the change in d-ROM values before and after the test and then examined its relationship with prognosis.
DOI: https://onlinelibrary.wiley.com/doi/10.1002/ehf2.13538
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