Finerenone Shows Consistent Efficacy in Heart Failure Regardless of Atrial Fibrillation Status: Study
Researchers have discovered in a study published in JAMA Cardiology that finerenone offers stable benefits in heart failure (HF) patients with mildly reduced or preserved ejection fraction, regardless of atrial fibrillation (AF) status. A new analysis of the FINEARTS-HF randomized clinical trial explored the effectiveness and safety of finerenone in these patients, focusing on outcomes in AF present and AF absent patients, including paroxysmal and persistent or permanent AF. The study was conducted by Shingo M. and colleagues.
There were 5984 patients with a mean age of 72.0 years (SD, 9.6) and a female percentage of 45.5%. Among the entire participants, 2714 (45.4%) were not having AF, 1384 (23.1%) were having paroxysmal AF, and 1886 (31.5%) were having persistent or permanent AF. Finerenone was given in titrated doses of 20 mg or 40 mg, and its effect was compared with that of a placebo. The main outcome assessed was a composite of total HF events and cardiovascular death, and new-onset AF or atrial flutter (AFL) was added as an exploratory endpoint.
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