Fluoroquinolones use linked to sudden cardiac death in dialysis patients: JAMA
A recent study published in the JAMA Cardiology finds the link between fluoroquinolone use with cardiac complications in the general population. Respiratory fluoroquinolone antibiotics are some of the most common medications with QT interval–prolonging potential prescribed to patients with hemodialysis-dependent kidney failure—individuals who have a very high risk of sudden cardiac death (SCD). To date, there have been no large-scale, population-specific studies evaluating the cardiac safety of respiratory fluoroquinolones in the hemodialysis population.
A team of researchers conducted a study to investigate the cardiac safety of respiratory fluoroquinolones among individuals with hemodialysis-dependent kidney failure.
A retrospective cohort study examining safety using an active comparator new-user design was conducted using administrative claims data from a US-wide kidney failure registry from January 1, 2007, to December 31, 2016, including 264 968 Medicare beneficiaries receiving in-centre maintenance hemodialysis. Data analysis was performed from January 4 to August 16, 2021.
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