Guided antiplatelet therapy efficacious and safe in percutaneous coronary intervention:Lancet

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-04-26 04:17 GMT | Update On 2021-04-26 09:02 GMT

According to recent research reports published in The Lancet,Guided selection of antiplatelet therapy improved both composite and individual efficacy outcomes with a favourable safety profile, driven by a reduction in minor bleeding, supporting the use of platelet function or genetic testing to optimise the choice of agent in patients undergoing PCI.

Whether guided selection of antiplatelet therapy in patients undergoing percutaneous coronary intervention (PCI) is effective in improving outcomes compared with standard antiplatelet therapy remains controversial. With this background, researchers assessed the safety and efficacy of guided versus standard selection of antiplatelet therapy in patients undergoing PCI.

For this systematic review and meta-analysis, from Aug 20 to Oct 25, 2020, the team searched MEDLINE (via PubMed), Cochrane, Embase, and Web of Science databases for randomised controlled trials and observational studies published in any language that compared guided antiplatelet therapy, by means of platelet function testing or genetic testing, versus standard antiplatelet therapy in patients undergoing PCI.

Coprimary endpoints were trial-defined primary major adverse cardiovascular events and any bleeding. Key secondary endpoints were all-cause death, cardiovascular death, myocardial infarction, stroke, definite or probable stent thrombosis, and major and minor bleeding.

Findings revealed some interesting facts.

3656 potentially relevant articles were screened. Our analysis included 11 randomised controlled trials and three observational studies with data for 20 743 patients.
Compared with standard therapy, guided selection of antiplatelet therapy was associated with a reduction in major adverse cardiovascular events (RR 0·78, 95% CI 0·63–0·95, p=0·015) and reduced bleeding, although not statistically significant (RR 0·88, 0·77–1·01, p=0·069).
Cardiovascular death (RR 0·77, 95% CI 0·59–1·00, p=0·049), myocardial infarction (RR 0·76, 0·60–0·96, p=0·021), stent thrombosis (RR 0·64, 0·46–0·89, p=0·011), stroke (RR 0·66, 0·48–0·91, p=0·010), and minor bleeding (RR 0·78, 0·67–0·92, p=0·0030) were reduced with guided therapy compared with standard therapy.
Risks of all-cause death and major bleeding did not differ between guided and standard approaches.
Outcomes varied according to the strategy used, with an escalation approach associated with a significant reduction in ischaemic events without any trade-off in safety, and a de-escalation approach associated with a significant reduction in bleeding, without any trade-off in efficacy.

For full article follow the link: https://doi.org/10.1016/S0140-6736(21)00533-X

Prmary source:THE LANCET

Article Source : The Lancet

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Dr Satabdi Saha

Dr Satabdi Saha (BDS, MDS) is a practicing pediatric dentist with a keen interest in new medical researches and updates. She has completed her BDS from North Bengal Dental College ,Darjeeling. Then she went on to secure an ALL INDIA NEET PG rank and completed her MDS from the first dental college in the country – Dr R. Ahmed Dental College and Hospital. She is currently attached to The Marwari Relief Society Hospital as a consultant along with private practice of 2 years. She has published scientific papers in national and international journals. Her strong passion of sharing knowledge with the medical fraternity has motivated her to be a part of Medical Dialogues.

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

Guided antiplatelet therapy efficacious and safe in percutaneous coronary intervention:Lancet

Similar News

Asthma Tied to Higher Risk of Heart Valve Disease, BMJ Study Finds

Stress Hyperglycemia Ratio and Hypertension Closely Associated with Stroke Risk: Study

Intermittent Fasting Under 8 Hours May Raise Heart Death Risk by 135 Percent: Study Finds

Evolocumab Plus Statins Shows Significant Intracranial Plaque Regression Compared to Statins Alone: Study

Chinese Herbal Foot-Baths Show Promise for Early-Stage Diabetic Foot Care: Study

How Dangerous Is Irregular Sleep for Heart Failure Survivors? Study Finds Out

Low-Dose Oral Minoxidil for Hair Loss Not Linked to Tachycardia, Large Study Suggests

Atopic Dermatitis Linked to 27 Percent Higher Stroke Risk, Meta-Analysis Finds