High CRP levels in Psoriasis Patients Increase Coronary Plaque Risk: JAHA
A recent study published in Journal of the American Heart Association uncovered a significant link between psoriasis, a chronic inflammatory condition, and the risk of coronary artery disease. The investigation was focused on the lectin-like low-density lipoprotein receptor-1 (LOX-1) and its soluble extracellular domain (sLOX-1), that plays a major role in triggering inflammation associated with psoriasis.
The study which involved 327 psoriasis patients revealed that those with elevated levels of sLOX-1 were more prone to displaying vulnerable coronary plaque features. The research delved into the relationship between sLOX-1 and inflammatory markers, particularly high-sensitivity C-reactive protein (hs-CRP).
The participants with sLOX-1 levels more than the median showed increased burdens of total, noncalcified, fibro-fatty, and necrotic coronary plaque features. The association between sLOX-1 and noncalcified and fibro-fatty burdens persisted despite the adjustments for various factors.
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