High dosage RAS blockade linked to improved survival after TAVR, finds study
According to a study published in the Canadian Journal of Cardiology, researchers found that higher doses of renin-angiotensin system (RAS) blockade are associated with improved survival and beneficial left ventricular remodeling 3 years after transcatheter aortic valve replacement (TAVR).
Angiotensin-converting enzyme inhibitors (ACEIs) have been widely prescribed worldwide and have been associated with a reduction in cardiovascular mortality in a large range of patients with cardiovascular disease, and in patients at risk for negative cardiovascular outcomes.
Though a growing body of evidence from retrospective studies has suggested that the renin-angiotensin system (RAS) blockade is associated with improved outcome after transcatheter aortic valve replacement (TAVR), however, it remains unknown whether the effect of RAS blockade is dose-dependent.
The present study by Jakob Ledwoch et al, at the Technical University of Munich, Munich, sought to assess the dose-dependent effect of RAS blockade on survival and left ventricular (LV) remodeling after TAVR.
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